Tableting of floating pellets with verapamil hydrochloride: influence of type of tablet press.

Compression of powders and granules into cohesive mass is a complex and irreversible dynamic process. Mechanically, the compaction process consists of progressive strain on the powder mixture confiding it to a final volume and porosity. Compression of pellets into the tablet form is more complex. It should be taken into consideration not only pellets properties (their compressibility, shape, porosity, mechanism of compression, brittle or plastic characteristic) and polymer film properties but also powder mass ñ matrix of tablet (their mechanism of compression, compressibility) (1-3). The aim of this paper was to evaluate the influence of type of tablet press on the tableting of floating pellets with verapamil hydrochloride and releasing rate of active substance. Presented evaluation is the continuation of studies concerns tableting of the floating pellets (4-6).